Haluk Barbaros ORAL, MD MSc PhD
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Haluk Barbaros ORAL, MD MSc PhD
Haluk Barbaros ORAL, MD MSc PhD Place and Date of birth: Bursa (Turkey) 26-07-1965 Nationality: Turkish Marital status: Married Wife: Arzu Yılmaztepe Oral Children: 1 girl (Gülin Oral) Languages: Turkish, English Addresses: Work: Department of Microbiology & Infectious Diseases, Immunology Unit Uludag University Faculty of Medicine Bursa / TURKEY Tel: 090 224 2954114 Fax: 090 224 2954941 E-mail: oralb@uludag.edu.tr Home: Konak Mah. Seçkin Sok. 1. Yücelkent Sitesi, Mutlu Ap. Kat:2 No:6 Bursa / TÜRKİYE EDUCATION & SCIENTIFIC ACTIVITIES 1970-1982 Primary, secondary and high school in Bursa, Turkey 1982-1988 Medical Faculty of Uludag University Bursa, Turkey 1988-1989 Obligatory work as a general practitioner Gercus, Mardin, Turkey 1989-1998 Infectious Diseases and Clinical Microbiology Specialisation. Uludag University School of Medicine, Microbiology & Infectious Diseases Department, Bursa, Turkey. Thesis: Evaluation of specific protective immune response in tuberculous pleurisy by different immunological parameters. Supervisor: Prof. Dr. Güher Göral 1993-1994 MSc in Immunology. Department of Immunology, Imperial College Hammersmith Hospital(Formerly; Royal Postgraduate Medical School), London, UK Thesis: “The use of calcein-AM to measure the response of an endothelial derived cell line (EA-hy-926) to hydrogen peroxide.” Supervisors: Prof. Dorian Haskard & Prof. Andrew George 1994-1997 PhD in Immunology. Department of Immunology, Imperial College, Hammersmith Hospital, London, UK 2 Thesis: “Use of gene transfer to protect cells from oxidant-mediated injury” Supervisors: Prof. Dorian Haskard & Prof. Andrew George 1998-2002 Assistant Professor Uludag University, Department of Microbiology, Immunology Unit, Bursa, Turkey Lectures and courses on Immunology and Infectious diseases since 1998 2002 Research fellow (for 3 months) Swiss Institute of Allergy and Asthma Research, In collaboration with Prof. C. Akdiş 2002-2007 Associate Professor of Microbiology / Immunology Uludag University, Department of Microbiology, Immunology Unit, Bursa, Turkey 2007 - Professor of Microbiology / Immunology Uludag University, Department of Microbiology, Immunology Unit, Bursa, Turkey MEMBERSHIP OF SCIENTIFIC SOCIETIES Turkish Immunology Society for Immunology (Vice President) Balkan Associations of Immunology Societies (General Secretary) Molecular Cancer Research Society (Board Member) Society of Turk Clinical Microbiology & Infectious Diseases Turkish Microbiology Society CONGRESS/COURSE ORGANIZATIONS National Symposium of Infection Immunology, 21-24 March 2002 Bursa, TÜRKİYE XVIIIth National Immunology Congress, 7-10 September 2005 Bursa, TÜRKİYE 2nd Mediterranean Clinical Immunology Meeting, 4-7 October 2008 Antalya, TÜRKİYE XXth National Immunology Congress, 6-9 November 2009, Girne, REPUBLIC OF NORTHERN CYPRUS Molecular Immunology & Imunogenetics Congress 2012 (MIMIC2012), 27-29 April 2012 Antalya, TÜRKİYE RESEARCH INTERESTS 1. T cell regulation in granulomatous infections (TB and Brucellosis). (Collaborators: Dr. A. Cezmi Akdiş, Switzerland; Dr. A. Whelan, U.K.; Dr. S. Costa Oliveira, Brazil) 2. Development of Immunotherapy Strategies against Cancers by targeting apoptosis pathway. (Collaborators: Dr. Salih Şanlıoğlu, Akdeniz U., Antalya-Turkey; Dr. Engin Ulukaya, Uludag U., Turkey) 3. Immunogenetics. Cytokine and cytokine-related gene polymorphisms in health and disease. 3 4. Gene Therapy. Development of Potential Immune gene therapy vectors and conditional gene expression strategies. SELECTED PUBLICATIONS: 1. Akdiş, A.C., K. Kılıçturgay, S. Helvacı, R. Mıstık, B. Oral. Immunologic evaluation of erythema nodosum in tularemia. Brit. J. Dermatol. 129, 275-279 (1993). 2. Larkin, D.F.P., H.B. Oral, C.J.A. Ring, N.R. Lemoine, A.J.T. George. Adenovirus-mediated gene delivery to the corneal endothelium. Transplantation 61, 363-370 (1996). 3. Fehervari, Z., S. Rayner, H.B. Oral, A.J.T. George, D.F.P. Larkin. Gene transfer to ex vivo stored corneas. Cornea 16,459-464 (1996). 4. Oral, H.B., D.F.P. Larkin, Z. Fehervari, A. Byrnes, A. Rankin, D.O. Haskard, M.J.A. Wood, M.J. Dalmann, A.J.T. George.ş Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea. Gene Therapy, 4, 639-647 (1997). 5. Arancibia-Cárcamo, C.V., H.B. Oral, D.O. Haskard, D.F.P. Larkin, A.J.T. George. Lipoadenofection mediated gene delivery to the corneal endothelium. Prospects for modulating graft rejection. Transplantation 65, 62-67 (1998). 6. Oral, H.B., A.J.T. George, D.O. Haskard. A sensitive fluorometric assay for determining H2O2-mediated sublethal and lethal cell injury. Endothelium 6, 143-151 (1998). 7. Oral, H.B., C.V. Arancibia-Cárcamo, D.O. Haskard, A.J.T. George. A method for determining the cytoprotective effect of catalase in transiently transfected cell lines and corneal tissue. Anal. Biochem. 267, 196-202 (1999). 8. Cockerill, G.W., J. Saklatvala, S.H. Ridley, H. Yarwood, N.E. Miller, B. Oral, S. Nithyanathan, G. Taylor, D.O. Haskard. High-density lipoproteins differentially modulate cytokine-induced expression of Eselectin and cyclooxygenase-2. Arterioscler. Thromb. Vasc. Biol. 19, 910-917 (1999). 9. Helvaci, S., S. Gedikoglu, H. Akalin, H.B. Oral. Tularemia in Bursa, Turkey: 205 cases in ten years. Eur. J. Epidemiol. 16, 271-276 (2000). 4 10. George, A.J.T., C.V. Arancibia-Cárcamo, H.M. Awad, R.M. Comer, Z. Fehervari, W.J. King, M. Kadifachi, T. Hudde, C. Kerouedan-Lebossé, F. Mirza, H.B. Oral, S.A. Rayner, P.H. Tan, E. Tay, D.F.P. Larkin. Gene delivery to the corneal endothelium. Am. J. Respir. Crit. Care Med. 162, S194-S200 (2000). 11. Oral, H.B., C. Özakın, A.C. Akdiş. Back to the future: Antibody-based strategies for the treatment of Infectious Diseases. Mol. Biotechnol. 24, 225-239, (2002). 12. Kılıç, S.S., H.B. Oral, F. Budak, H. Aydoğdu, B. Yavaşcaoğlu, G.Göral. Immunoglobulin subclasses and HLA alleles in immunoglobulin A deficiency. Ind. J. Ped. 70, 389-392, (2003). 13. Tuncer, L.I., T. Alaçam, B. Oral. Substance P expression is elevated in inflamed human periradicular tissue. J. Endodon. 30, 329-32 (2004). 14. Ersoy C., S. Imamoğlu, F. Budak, E. Tuncel, E. Ertürk, B. Oral. Effect of amlodipine on insulin resistance & tumor necrosis factor-alpha levels in hypertensive obese type 3 patients. Indian J. Med. Res. 120, 481-8 (2004). 15. Yilmaz, E., M. Parlak, H. Akalin, Y. Heper, C. Ozakin, R. Mistik, B. Oral, S. Helvaci, O. Töre. Brucella Spondylitis: Review of 25 cases. J. Clin. Rheumatol. 10, 300-7 (2004) 16. Baştürk, B., İ. Yavaşçaoğlu, H. Vuruşkan, G. Göral, B. Oktay, H.B. Oral. Cytokine gene polymorphisms as potential risk and protective factors in renal cell carcinoma. CYTOKINE 30, 41-45 (2005). 17. Gonullu, G., C. Ersoy, A. Ersoy, T. Evrensel, B. Basturk, E. Kurt, B. Oral, S. Gokgoz, O. Manavoglu. Relation between insulin resistance and serum concentrations of IL-6 and TNF-α; in overweight or obese women with early stage breast cancer. CYTOKINE 31, 264-269 (2005). 18. Koç, M., D. Ediger, F. Budak, M. Karadağ, H.B. Oral, E. Uzaslan, E. Ege, O. Gözü. Matrix metalloproteinase-9 (MMP-9) elevated in serum, but not in bronchial lavage in lung cancer patients. TUMORI 92, 149-154 (2006). 19. Oral, H.B., S.V. Kotenko, M. Yılmaz, O. Mani, J. Zumkehr, K. Blaser, A.C. Akdis, M. Akdis. Regulation of T cells and cytokines by interleukin-10-family cytokines IL-19, IL-20, IL-22, IL-24 and IL26. Eur. J. Immunol. 36, 380-388 (2006). 5 20. Kiyici, M, S.G. Nak, F. Budak, S. Gurel., B. Oral, E. Dolar, M. Gulten. Lymphocyte subsets and cytokines in ascitic fluid of decompensated cirrhotic patients with and without spontaneous ascites infection. J. Gastroenterol. Hepatol. 21, 963-9 (2006) 21. Basturk, B., İ. Yavascaoglu., B. Oral, B. Oktay, G. Göral. Cytokine Gene Polymorphisms Can Alter The Effect Of Bacillus Calmette-Guérin (BCG) Immunotherapy. CYTOKINE 35, 1-5 (2006). 22. Oral, H.B., F. Budak, E.K. Uzaslan, B. Baştürk, A. Bekar, H. Akalın, E. Ege, B. Ener, G. Göral. Interleukin-10 (IL-10) Gene Polymorphism As A Potential Host Susceptibility Factor In Tuberculosis. CYTOKINE 35, 143-147 (2006). 23. Heper, Y., E.H.Akalın, R. Mıstık, S. Akgöz, O. Töre,G. Göral, B. Oral, F. Budak, S. Helvacı. Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community acquired sepsis, severe sepsis, and septic shock. Eur J Clin Microbiol Infect Dis 25, 481–91 (2006) 24. Kiyici, S., E. Erturk, F. Budak, C. Ersoy, E. Tuncel, C. Duran, B. Oral, D. Sigirci, S. Imamoglu. Serum monocyte chemoattractant protein-1 and monocyte adhesion molecules in type 1 diabetic patients with nephropathy. Arch Med Res. 37, 998-1003 (2006) 25. Ursavas, A., M. Karadag, E. Rodoplu, A. Yilmaztepe, H.B. Oral, R.O. Gozu. Circulating ICAM-1 and VCAM-1 Levels in Patients with Obstructive Sleep Apnea Syndrome. Circulating ICAM-1 and VCAM-1 Levels in Patients with Obstructive Sleep Apnea Syndrome. Respiration 74, 525-32 (2007). 26. Bakir Ozbey, S, R. Mistik, E. Gürcüoğlu, B. Oral, G. Goral. Polyclonal activation due to Epstein-Barr virus superinfection in a case with chronic hepatitis B. Mikrobiyol Bul. 41, 607-12 (2007). 27. Budak, F., G. Göral, Y. Heper, E. Yılmaz, F. Aymak, B. Baştürk, O. Töre, B. Ener, H.B. Oral. IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis. CYTOKINE 38, 32-36 (2007). 28. Gonullu, G., B. Basturk, T. Evrensel, B. Oral, A. Gozkaman, O Manavoglu. Association of breast cancer and cytokine gene polymorphism in Turkish women. Saudi Med J. 28, 1728-33 (2007). 28. Basturk, B., Z. Karasu, M. Kılıç, S. Ulukaya, S. Boyacioglu, B. Oral. Association of TNF-α -308 polymorphism with the outcome of Hepatitis B virus infection in Turkey. Infections, Genetics and Evolution 8, 20-5 (2008). 6 29. Colakogullari, M, E. Ulukaya, A. Yilmaztepe-Oral, F. Aymak, B. Basturk, A. Ursavas, H.B. Oral. The involvement of IL-10, IL-6, IFN-γ and TGF-β gene plymorphisms among Turkish lung cancer patients. Cell Biochemistry and Function Cell Biochem Funct. 26, 283-90 (2008). 30. Ursavas, A., M. Karadag, A.Yilmaztepe Oral, E. Demirdogen, H.B. Oral, E. Ege. Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea. Respir Med. 102, 1193-7 (2008). 31. Bulent Gul, C.B., M. Gullulu, B. Oral, A. Aydinlar, O. Oz, F. Budak, Y. Yilmaz, M. Yurtkuran. Urinary IL-18: a marker of contrast-induced nephropathy following percutaneous coronary intervention? Clin Biochem. 41, 544-7 (2008). 32. Ersoy, C., S. Kiyici, F. Budak, B. Oral, M. Guclu, C. Duran, H. Selimoglu, E. Erturk, E. Tuncel, Imamoglu S. The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients. Diabetes Res Clin Pract. 81, 56-60 (2008). 33. Budak, F., E.K. Uzaslan, S. Cangür, G. Göral, H.B. Oral. Increased Pleural Soluble Fas Ligand (sFasL) Levels in Tuberculosis Pleurisy and Its Relation with T-helper Type 1 Cytokines. Lung 186, 337-43 (2008). 34. Budak, F., G. Göral, H.B. Oral. Saccharomyces CerevisiaeBeta-Glucan Induces Interferon-Gamma Production in Human T Cells Via IL-12. Tr J Immunol. 13, 21-6 (2008). 35. Oral, H.B., G. Deniz, M. Zouali. Functional imaging in the immune system. Eur J Immunol. 39, 7-10 (2009). 36. Deniz, G., H.B. Oral, M. Zouali. Frontiers in clinical immunology 2008. Scand J Immunol. 2009 Aug;70(2):163-71. 37. Dilek, K., A.A. Özçimen, H. Sarıcaoglu, D. Saba, A. Yücel, M. Yurtkuran, M. Yurtkuran, H.B. Oral. Cytokine gene polymorphisms in Behçet's disease and their association with clinical and laboratory findings. Clin Exp Rheumatol. 2009; 27 (suppl.53): S73-S78. 38. Ozerkan, K., G. Uncu, B. Oral. Mannose-binding lectin levels in endometriosis. Fertil Steril. 94(2), 775-6 (2010). 39. Kazak, E., S.C. Oliveira, G. Goral, H. Akalin, E. Yilmaz, Y. Heper, H.B. Oral. Brucella abortus L7/L12 recombinant protein induces strong Th1 response in acute brucellosis patients. Iran J Immunol. 7: 132-41 (2010). 7 40. Gürcüoğlu, E., H. Akalın, B. Ener, G. Ocakoğlu, M. Sınırtaş, Sevim Akçağlar, E. Yılmaz, C. Evci, B. Oral. Nosocomial candidemia in adults: Risk and prognostic factors. Journal de Mycologie Médicale 20: 269-78 (2010). 41. Oral, H.B., K. Dilek, K, A.A. Özçimen, Ö. Taşkapılıoğlu, Ü. Bingöl, A. Sarandöl, H. Sarıcaoğlu, M. Yurtkuran, M.A. Yurtkuran. Interleukin-4 gene polymorphisms confer Behçet’s Disease in Turkish Population. Scand J Immunol 73: 594-601 (2011). 42. A.A. Özçimen, K. Dilek, Ü. Bingöl, H. Sarıcaoğlu, A. Sarandöl, Ö. Taşkapılıoğlu, M. Yurtkuran, M.A. Yurtkuran, H.B. Oral. IL-1 cluster gene polymorphisms in Turkish patients with Behçet’s Disease. Int J Immunogenet 38: 295-301 (2011). 43. Karali, Z., S. Tanir Basaranoglu, Y. Karali, B. Oral, S.S. Kilic. Autoimmunity and Hepatitis A Vaccine in Children. J Investig Allergol Clin Immunol 21: 389-93 (2011). 44. Özkan, H., N. Köksal, M. Çetinkaya, Ş. Kılıç, S. Çelebi, B. Oral, F. Budak. Serum Mannose Binding Lectin (MBL) Gene Polymorphism and Low MBL Levels Are Associated with Neonatal Sepsis and Pneumonia. J Perinatology (in press) REFEREED JOURNALS Archives of Medical Research BMC Medical Genetics Clinical Applications of Immunology Cytokine Diagnostic Microbiology and Infectious Disease European Journal of Clinical Microbiology & Infectious Diseases FEMS Immunology & Medical Microbiology Genetic Testing and Molecular Biomarker Human Immunology International Journal of Immunogenetics Iranian Journal of Immunology Journal of Biological & Environmental Sciences (JBES) Journal of Clinical Immunology & Allergy Journal of Oral Pathology and Medicine Klimik Journal Turkish Journal of Immunology JOURNAL EDITORIAL BOARD EXPERIENCE Turkish Journal of Immunology Clinical Applications of Immunology 8 Klimik Journal TRAINED MEDICAL FELLOWS AND POSTGRADUATE STUDENTS Zoltan Fehervari, MSc (1995-1996) (Imperial College, London) Carolina Arancibia, MSc (1996-1997) (Imperial College, London) Esra Kazak, MD (2001-2006) (Uludag University, Turkey) Ferah Budak, PhD (2001-2006) (Uludag University, Turkey) Arzu Yılmaztepe Oral, PhD (Pending) (2005-Current) Emel Bülbül Başkan, PhD (Pending) (2006-Current) Ümit Bingöl, PhD (Pending) (2007-Current) Ayşe Ayarcı, MD (Pending) (2007-Current) Salih Haldun Bal, PhD (Pending) (2008-Current)