Janus.avi - ozonio.com.br
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Janus.avi - ozonio.com.br
..\Janus.avi Milestones of Medical Ozone Renate Viebahn-Hänsler, Iffezheim 22.03.02 RV OZONOSAN 2 Milestones of Medical Ozone Ozone Treatment in Surgery § § § § § § Werkmeister 1915 A. Wolff, Berlin,Germany 1935 E. Payr, Leipzig, Germany 1937 P. Aubourg, Paris, France 1977 O. Rokitansky, Vienna, Austria 1981 H. Werkmeister, Oberhausen, Germany 1987 H.G. Knoch, Dresden, Germany 22.03.02 RV OZONOSAN 3 Milestones of Medical Ozone Ozononised Water in Dental Medicine § 1935 E.A. Fisch, Locarno, Switzerland § 1976 R. Türk, Bad Pyrmont, Germany § 1991 H. Kirschner, Giessen,Germany A. Filippi, Basel, Switzerland Brauner 22.03.02 RV OZONOSAN 4 Milestones of Medical Ozone Applications: Topical Treatments 2 § Transcutanous gas bath in ozone resistent plastic bags § 1958 J. Hänsler, H. Wolff, Iffezheim/ Frankfurt,Germany Indications: - Ulcus cruris, - Dermatosis, - Fungus infections 22.03.02 RV OZONOSAN 5 Milestones of Medical Ozone Applications: Topical Treatments 1 § § Low pressure ozone gas application 1981 H. Werkmeister Oberhausen, Germany Indications: 22.03.02 RV OZONOSAN Decubitus ulcers, Diabetic gangrene, Fistulas and Badly healing wounds 6 Milestones in Medical Ozone Applications: Rectal Insufflation § 1937 P.Aubourg, Paris, France § 1987 H.G. Knoch, Dresden, Germany Indications: - 22.03.02 RV OZONOSAN Proctitis Colitis 7 Milestones in Medical Ozone Applications: Major Autohaemotherapy § Major Autohaemotherapy as extracorporeal blood treatment avoiding intravascular gas application forms. § 1968 H. Wolff, Frankfurt, Germany Indications: 22.03.02 RV OZONOSAN Arterial circulatory disorders Immunomodulation Rheumatoid arthritis 8 Milestones of Medical Ozone Applications: Intraarticular Injections in Orthopedics § 1981 Z. Fahmy, Bad Kreuznach, Germany § 1989 E. RivaSanseverino, Bologna, Italy Indications: 22.03.02 - Knee arthrosis, Gonarthrosis and rheumatoid arthritis as supportive therapy RV OZONOSAN 9 Milestones of Medical Ozone Pharmacological Effects 1: Red Blood Cells Oxygen saturation § § § § 1975 Buckley et al. 1979 Freeman et al. 1977-1986 Washüttl et al. 2001 Lell et al. § Peroxide formation and activation of the RBCmetabolism via the glutathion system with improvement of oxygen release without DPG with DPG Oxygen partial pressure pO2 in mm Hg 22.03.02 RV OZONOSAN 10 Milestones of Medical Ozone Pharmacological Effects 2: immunocompetent cells § 1990 Bocci et al. § Induction of cytokins Cytokin induction in % dep.on O3-conc. 450 400 350 oxygen 300 250 11 µg 200 25 µg 150 42 µg 100 50 0 such as interferons, interleukins and growth factors 78 µg IFN-γ IFN-g 22.03.02 IL-6 TNF-α TNF-a RV OZONOSAN 11 Milestones of Medical Ozone Pharmacological Effects 3: Radical Scavengers 70 Protective effect of ozone in 60 Hepatic Ischaemia - Reperfusion 50 40 30 20 10 0 H2O2 Kontrolle 22.03.02 SOD Ischaemia/Reperfusion § § 1998 León, Bocci et al. 1999 Peralta et al. § Activation of antioxidative enzymes and radical scavengers as protective effect in damage by free radicals GSH Ozone+I/R RV OZONOSAN 12 Milestones in Medical Ozone Pharmacological Effects 4: Ozone and Prevention Survival rate in lethal septic peritonitis § 1999 Schulz et al. 100% 80% - 60% 40% 20% 0% ozone III anibiotic IV O3+antib. V - control Parasitaemia in % § 2001 Lell et al. 35 - 30 25 20 15 10 5 0 day 1 day 2 Parasites 22.03.02 Improvement of survival rate in septic peritonitis in an animal model by pretreatment with ozone. Synergistic effect with antibiotics. day 3 day 4 day 5 Growth inhibitory effect of plasmodium in infected RBC´s by pretreatment with ozone. day 6 Ozone+Par. RV OZONOSAN 13 Indications of Ozonetherapy Today and the Pharmacological Background Indications Mechanism of Action § § Disinfection, wound cleansing § § § External ulcers and skin lesions Arterial circulatory disorders Immunodeficiency and immunodisbalance Inflammatory conditions § Dental Medicine § Activation of RBC-metabolism Activation of immunocompetent cells Activation of antioxidants and radical scavengers Disinfection, woundhealing § § 22.03.02 § RV OZONOSAN 14
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