biolegend.com
Transkript
biolegend.com
Chemokine Receptor Biology 04-0021-00 INFLAMMATION HOMEOSTASIS Bone Marrow Periphery CXCR4 Rolling Neutrophil CXCR4 LFA-1 ICAM-1 CXCR1, 2 CXCL8 Blood Vessel T Progenitor CCR7 CCR7 Bone Marrow Niche CCR9 CCL19 CCL25 CCL21 CD34 HSC IFN-γ Pro-inflammatory CXCL8 Cytokines TNF-α IL-1 Thymus Tissue CXCL8 Positive Selection Egress Medulla Cortex Single Positive Thymocyte CCL19, 21 CCL20 CXCR4 CXCR1 CXCL1, 2, 3, 5, 6, 7, 8 CCR8 CCR9 CXCL9, 10, 11 CCL2 Chemokine Sequestration Chemokine Receptor Signaling HIV ? CXCL11, 12 CXCL16 Extracellular CXCR6 CCR5 Viral CCL1, 2, 3 Respiratory Burst Granule Release CCL2, 3, 5 17, 22 CCL5, 7, 11, 13, 14, 15, 24, 26 CCR4 CXCL13 CXCR4 CXCL12 XCR1 XCL 1,2 STK’s, Ras Cytoskeletal Remodeling Shape Change Firm Adhesion CX3CR1 Block Recruitment of Dendritic Cells, Lymphocytes Receptor Internalization/ Desensitization KSHV CCL3, 4, 5, 7 14, 15, 16 E1 CXCL1, 5, 7 US28 CXCL12: SDF-1 CXCL4: PF-4 CXCL8: IL-8 CXCL13: BCA-1, BLC CXCL9: CMK, MIG, SCYB9 CXCL14: BRAK, Bokeline CXCL10: IP-10 CXCL15: LUNGKINE, SCYB15 CXCL11: I-TAC CXCL16: SCYB16, SR-PSOX Angiogenesis Tumor Cells CCL2, 3, 4, 5, 7 Blood Vessel CCL2, 3, 4, 5 Tumor Metastasis CXCL1, 8, 10, 12 CCL11 Recruitment CCR7: Breast, Melanoma, Head and Neck, Colorectal, Chronic Lymphocytic Leukemia, Stomach, Non-Hodgkin’s Lymphoma, T Cell Leukemia CCR9: Melanoma CCR10: Melanoma CXCR3: Acute Lymphoblastic Leukemia CXCR4: Breast, Ovarian, Prostate, Pancreatic, Melanoma, Oesophageal, Non-small Cell Lung, Head and Neck, Bladder, Colorectal, Osteosarcoma, Neuroblastoma, Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia, Stomach We would like to thank Dr. Albert Zlotnik, University of California, Irvine for his contributions to this poster. CXCL7: NAP-2 CXCL12 Upregulation of Chemokine Receptors CXCR4 Interactive Poster: biolegend.com/chemokinebiology CXCL3: GRO3, GRO-γ, MGSA-γ, MIP-2β, SCYB3 Immunosuppression Hypothetical Primary Tumor Site ECRF3 UL12 CCR1 Treg Recruitment Metastasis/Angiogenesis VEGF 9727 Pacific Heights Blvd. San Diego, CA 92121 | Email: cs@biolegend.com CXCR5: Head and Neck Cancer US & Canada Toll-Free: 1.877.246.5343 (877-BIOLEGEND) | International: 1.858.768.5800 CXCL6: SCYB6, GCP 2, CKA-3 CCR7, 10 CXCL1, CXCL8 CCL26, CX3CL1 biolegend.com Kaposi Sarcoma Virus Immunosuppression CXCL5: ENA-78, LIX CCL28 CXCR4 CCR2 CCL2, 7, 8 12, 13 CCR8 Arrestin, PLCβ2 PLCβ2, PLD, PKC CCR4 Treg, Th2 Recruitment CXCL2: CINC-2α, GRO2, GROβ, GROB, MGSA-β, MIP2 CCR7 CCL27, CXCL14 Tumor Cells CXCR5 Membrane Immunosuppression CD4 CXCL1: GRO1, GROα, MGSA, NAP3, SCYB1, MGSA-α Dendritic Cell Oxysterols CXCR7 Chemokine Receptor CCR3 Immune Tolerance Chemokine Nomenclature CANCER Tumor Defense CXCL14 G Proteins US28 Endothelial Cell CXCR7 CX3CR1 CCR9 α4β7+ T cell ? CXCR3 Cytomegalovirus CCR8 CXCR6 Small Intestine Skin: CCL27, CXCL14 CLA+ T cell ? CCL5 Macrophage Dendritic Cell CCR10 CCR7 CCL3, 4, 5, 8, 14 B cell CCL25 Intracellular CD4 CCR5 ? Tumor Cell Proliferation CCL19, 21 CCL2, 3, 5, 7 CXCL17 CCR10 Reduced Recruitment HIV CCL27 CCL18 T Cell CCR2 D6 CCL19 T cell Small Intestine: CCL25, CXCL17 Dermal Cells Chemokine CXCR2 CD4 CCR7 Spleen: CCL19, CCL21, CXCL13 Liver: CXCL13 CXCL17 + CCL27, 28 CCR7 CXCL6, 8 Macrophage CCR2 CCR3 Atypical Lymph Nodes: CCL19, CCL21, CXCL13 Bone Marrow: CXCL12 Mature CD4 or CD8 Naïve T Cell + CCL25 CCL1, 4 CCR6 B cell HEV Skin Negative Selection Epithelium Chemokine Sink CXCR4 CD4+ or CD8+ CCR7+, CCR9+ CD4+CD8+ Thymocyte Injury, Infection CXCR5 Brain: CXCL12, CXCL14 Lungs: CXCL12, CXCL17 G-CSF Sphingosine1-Phosphate Receptor Cortico-medullary Junction CXCR4+, CCR7+, CCR9+ CD4-CD8Thymocyte Chemokine Gradient Other Reported HIV Co-Receptors CXCR5 T cell CXCL13 CXCL12 Endothelium + CCR5 T cell Zone Endothelium Blood Endothelium HIV DUFFY CCL21 PSGL-1 P-Selectin HIV Entry Follicle CCR9 E-Selectin VIROLOGY CXCL1, 8 CCL2, 5 T Progenitor Specialized Stromal Cells Sphingosine-1-Phosphate Gradient Secondary Lymphoid Tissues Hypothetical Secondary Tumor Site CXCL17: DMC, VEGF Co-regulated Chemokine 1 CCL1: I-309, TCA-3, SCYA1 CCL6: C10, MRP1 CCL12: MCP-5 CCL17: TARC, ABCD 2 CCL22: MDC, ABCD 1 CCL27: CTACK, ESKine, ILC, Skinkine Th17: CCR4, 6 Cell Expression Dendritic Cells: CCR1, 2, 5, 6, 7; CXCR1, 2, 4 Eosinophils: CCR3, CXCR4 CCL7: MCP-3, MARC CCL13: MCP-4 CCL18: DC-CKA1, PARC, MIP-4, AMAC-1 CCL23: MIP-3, CKb-8, MPIF-1 CCL28: MEC, CCK1 Th22: CCR4, 6, 10 Hematopoietic Stem Cells: CXCR4 CCL3: MIP-1α CCL8: MCP-2, HC14 CCL14: HCC-1, HCC-3, MCIF, NCC2 CCL19: ELC, MIP-3β, Exodus-3 CCL24: MPIF-2, Eotaxin-2, CKβ-6 Tfh: CXCR5 Naïve T Cells: CCR7, CXCR4 CCL4: MIP-1β, ACT-2, H400 CCL9: CCL10, MRP-2, MIP-1γ, CCF18 CCL15: MIP-1δ, MIP 5, MRP-2B, NCC3, HCC-2 CCL20: LARC, MIP-3α, Exodus-1 CCL25: TECK, CKβ-15 T Helper Cell Expression Natural Killer Cells: CCR2, 4, 5, 8; CXCR1, 3, 4; CX3CR1 Mast Cells: CCR1, 3, 4, 5; CXCR1-4 CX3CL1: Fractalkine, Neurotactin CCL2: MCP-1, MCAF, JE Treg: CCR2, 4, 5, 6, 8-10; CXCR4-6 B Cells: CCR7, CXCR4, 5; CX3CR1 Neutrophils: CCR1; CXCR1, 2, 4 Epithelial Cells: CCR1-8; CXCR1, 4 CCL5: RANTES CCL11: Eotaxin, Eotaxin 1 CCL16: HCC-4, LEC, LCC-1 CCL21: SLC, 6Ckine, Exodus-2 CCL26: Eotaxin-3 XCL1: Lymphotactin, ATAC, SCM-1α XCL2: SCM-1β Th1: CCR5, CXCR3 Th2: CCR3, 4, 8; CXCR5 Macrophages: CCR1, 2, 5; CXCR1, 4 Basophils: CCR1-4, CXCR4 Endothelial Cells: CCR1-4; CXCR1-4
Benzer belgeler
PRODUCT CODE PRODUCTS NAME QUANTITIY MANUFACTURE
Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human) - EIA Kit, Host: Rabbit, High Sensitivity Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human) - Immunofluorescence Kit, Host: Rabbit
DetaylıDoor Closers
Ingersoll-Sergeant Drill ve Rand Drill firmalar›n birleflmesi ile kurulmufltur. Ancak, baz› Ingersoll Rand iflletmelerinin kuruluflu 1871'lere kadar gitmektedir. Tarih boyunca, Ingersoll Rand ürünleri ...
Detaylı